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Both flu (influenza) and cold are caused by viruses, and they can have similar symptoms. So how do we know if a person has the flu or a bad cold? In this article, we explain the differences. Cold and influenza are the most common illnesses in humans, according to an article published in The Lancet Trusted Source . Every year, 5-20 percent of the population of America develop flu symptoms. The main difference between cold and flu is that, generally, symptoms of the flu are usually a lot more severe. Each year, more than 200,000 people are hospitalized because of flu complications; flu is responsible for around 23,600 deaths every year. Fast facts on colds vs. flu : Colds and flu share many of the same symptoms; the major difference being flu is often worse, and accompanied by a high fever . According to the Centers for Disease Control and Prevention (CDC), the average adult will have 2-3 colds every year. The rhinovirus is the most common cause of cold. The d...